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Tuschl II siRNA Assay
Knock-down of nuclear envelope protein Lamin. Elbashir, Harborth et al. Nature May 24 2001. This assay was proposed by Klaus Weber.
« Two Sides to the Story: Defendants’ Summary of the Evidence in this Case
Two Sides to the Story: Plaintiffs’ Summary of the Evidence in this Case »

The Probable Length of the Trial

May 11th, 2010 | Author: johnleavitt

The start date for the trial currently scheduled for June 1st will probably be set at the pretrial hearing next Monday, May 17th.

[from Case 1:09-cv-11116-PBS Document 350 Filed 05/10/10]

A. Plaintiffs’ Statement
Plaintiffs estimate that this matter will require fourteen full trial days in addition to empanelment of the jury.
B. Defendants’ Statement
Defendants estimate that trial of this matter will require eleven trial days, assuming a 9 am to 1 pm daily trial schedule.

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What is siRNA?
Elbashir etal. (left sidebar): "Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi) ... 21- and 22-nt RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III–like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3' ends mediate efficient target RNA cleavage ..." and "... (these) 21-nucleotide siRNA duplexes specifically suppress expression of endogenous and heterologous genes in different mammalian cell(s)..."
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